For people suffering from diseases of the bones, joints and muscles, doctors often prescribe Nimid (tablets) as symptomatic therapy. Instructions for use contain information that this drug not only relieves pain, but also has an anti-inflammatory effect. Let's try to study the characteristics of the drug in more detail and figure out in what cases it can help.
Forms of the drug and their composition
As for the forms of the medicine, today you can buy tablets, suspension, granules and gel in pharmacies. The main active ingredient in them is nimesulide. The tablet form of the drug is available in blisters of 10 pcs. One tablet contains 100 mg of nimesulide, and pharmacists used microcrystalline cellulose, sodium stearate, sodium croscarmellose and aerosil 200 as auxiliary components. This is the information about the composition of the drug "Nimide"(tablets) instructions for use.
The powder is available in dosed sachets. This form of the drug is convenient to use for the treatment of children. Indeed, in addition to nimesulide, povidone K-30, tabletose 80 and aerosil 200, the composition contains such excipients as sodium saccharin, citric acid and flavors. The baby will gladly drink a delicious healing “cocktail” prepared by his parents.
1 ml of suspension and 1 g of gel contains 100 mg of nimesulide. The auxiliary components in these two forms are propylene glycol, sodium hydroxide, carbomer 940, disodium edelate, fragrance, purified water and methylparaben.
Pharmacological action of the drug
Nimesulide, which is the active substance of this medication, belongs to the group of non-steroidal anti-inflammatory sulfonanilides. Once in the human body, it selectively inhibits COX-2 and suppresses the synthesis of prostaglandins in the focus of the inflammatory process. Analgesic, antipyretic and anti-inflammatory effect is achieved after taking one "Nimide" tablet. The instructions for use contain more information regarding the dosage of the drug.
In addition to all of the above, the drug is able to inhibit the release of oxygen free radicals and inhibit the release of myeloperoxidase, while not affecting the processes of phagocytosis and chemotaxis.
As for the anti-inflammatory effect of the drug, it is achieved due to the ability of nimesulidesuppress mediators of the inflammatory process and reduce tumor necrosis factors. By inhibiting the synthesis of interleukin-6 and urokinase, the Nimid preparation (instruction for use confirms this fact) prevents the destruction of proteoglycans and collagen in cartilage tissue. In addition, nimesulide blocks the conduction of pain impulses through the nociceptive system.
If we consider the mechanism of analgesic action, then it is associated with the inhibition of the release of histamine from numerous mast cells and the effect of the active substance on glucocorticosteroid receptors.
If the doctor prescribed Nimid (tablets), the instructions for use should be carefully studied even before taking the medicine. After all, this document contains recommendations that must be taken into account throughout the course of therapy.
Pharmacokinetics
After taking the recommended dose, the drug is actively absorbed from the gastrointestinal tract. And after 1.5-2.5 hours, the maximum concentration of the active substance in the blood plasma is noted. A characteristic feature of the drug is its high ability to interact with proteins, as well as to penetrate through the blood-brain and hematoplacental barriers. In high concentrations, nimesulide is determined in the focus of the inflammatory process and in the synovial fluid.
The drug is metabolized in the liver, then, mostly in the unchanged form of active metabolites, it is excreted through the kidneys (with urine), less - with feces. Half-life of the active substanceachieved in 3.5-5 hours. Contains more specific pharmacokinetic data on the drug "Nimide" instructions for use.
Indications
Effective drug for fever, which accompanies diseases of the ENT organs and upper respiratory tract. Quite often, the drug is prescribed to people suffering from rheumatoid arthritis, myalgia, osteoarthritis, bursitis, tendinitis, as well as other diseases of the muscles, joints and bones, accompanied by pain. In dental and gynecological practice, for postoperative and post-rheumatic pains, the Nimid medication is also used. Instructions for use in such cases recommends purchasing tablets, powder or granules.
As for the drug in the form of a gel, it is intended for topical application for inflammation of the tissues (soft), which are caused by various injuries. The remedy is also effective in inflammatory processes and degenerative diseases of the musculoskeletal system, osteoarthritis, Bechterew's disease, etc. Contains an extended list of indications for the use of Nimid, instructions for use from the manufacturer.
Reception conditions and dosing system
If we are talking about taking medicine in the form of tablets, suspensions, then you need to use it only after eating. It is desirable that at least 20 minutes pass after eating, otherwise the pharmacokinetic action of nimesulide slows down. As for the dosage of the drug and the duration of the course of treatment, these questionsthe attending physician should answer directly, taking into account the individual characteristics of the patient and the severity of the disease. Therefore, we will consider only the general recommendations that the instructions for use contain about the Nimid medicine.
Tablets for adults are usually prescribed twice a day for 100 mg. In severe forms of the disease, the daily dose can be doubled. Adolescents from 12 to 18 years old are recommended to calculate the dosage of the drug at the rate of 1.5 mg per 1 kg of body weight. If treatment is required for a child under the age of twelve, and his weight exceeds 40 kg, he is prescribed 100 mg of medication per day, dividing the rate into two doses. In exceptional cases, the doctor may increase the recommended dose.
The product in the form of granules is prescribed for children from 12 years old and adults, 1 sachet in the morning and evening. The contents of the sachet are diluted in 100 ml of warm water and drunk after meals.
As for Nimid gel, it is applied (without rubbing) in a thin layer - no more than 4 times a day - to the area of the body with the most pronounced pain syndrome. After using the medication, wash your hands thoroughly with soap and running water.
Who is the drug contraindicated for?
Do not prescribe medicine to people with peptic ulcer, severe disorders in the liver and kidneys, as well as with a history of hepatotoxic reactions to nimesulide. The drug is categorically contraindicated with a tendency to various bleeding, heart failure and hypersensitivity to one or more components of the Nimid Forte medication. Instructions forapplication also contains information on the prohibition of the use of the drug in combination with potentially hepatotoxic drugs, with fever, flu-like conditions and suspected acute surgical pathology.
As for the product in the form of a gel, it is not prescribed to patients under 12 years of age and people prone to allergic reactions. The use of the drug can aggravate the course of the disease with dermatitis, skin lesions and infections, as well as with bronchial asthma, which is caused by ASA. That is why, with the above pathologies, the Nimid remedy is not prescribed. Instructions for using the pill in such cases also do not recommend using it.
Can I take medicine during pregnancy?
Scientists have found that nisumelide can affect fertility. In addition, it inhibits prostaglandin synthesis, which is known to be the cause of oligohydramnios, pulmonary hypertension, oliguria, and premature narrowing of the Batal duct. The risk of weakening labor activity, the occurrence of peripheral edema and bleeding may increase when using the Nimid medication. Instructions for use of tablets and other forms of medication are strictly prohibited both during pregnancy and lactation.
After all, the active substance, together with breast milk, can enter the child's body and disrupt the functioning of its vital systems. In those cases where it is impossible to do without medication, and the benefit to the mother outweighs the riskcausing harm to the baby, the dosage and course of therapy is determined by the doctor.
Side effects
In addition to the mass of positive pharmacological characteristics, the drug also has an impressive list of side effects. So, let's see what reactions can occur when using Nimid. Tablets (instruction in Russian provides this data) can cause itching, urticaria, various skin rashes, angioedema, and in some cases even Stevens-Johnson syndrome and epidermal necrolysis. The gastrointestinal tract may, in turn, respond to the drug with constipation, diarrhea, sometimes patients experienced pain in the stomach, nausea. Very rarely, taking pills can cause perforation of the ulcer and peptic ulcer of the stomach and duodenum.
Since the process of metabolism takes place in the liver, it also suffers from it. Therefore, prolonged use of the drug in some cases can cause a change in the activity of transaminases, cholestasis, the development of jaundice and even acute hepatitis. The same disorders in the liver are caused not only by tablets and granules, but also by Nimid powder.
The instruction specifically describes the possible reactions of the genitourinary system when taking the medicine. It can be both edema, dysuria, urinary retention, and oliguria, acute renal failure, interstitial nephritis. On the part of the respiratory system, dyspnea and bronchospasm are possible, long-term use can cause the development of bronchial asthma.
In addition to the above effects,the patient may develop tachycardia, arterial hypertension, hypothermia, asthenia and other diseases. In almost all adverse reactions, it is recommended to stop the medicine and consult a doctor immediately. In order not to be in such a situation, it is necessary to carefully study all possible information about the drug and only then take Nimid Forte (tablets). The instructions for use, which is in each package of the drug, will help with this.
Drug overdose and first aid algorithm
If the allowable dose of the drug was accidentally exceeded, you should immediately go to the hospital. After all, the consequence of such an error can be drowsiness, nausea, vomiting, pain in espigastria, apathy, and increased blood pressure. And this is a list of only the mildest reactions of the body to an increased dose of Nimid. Tablets - the instruction warns about this - taken in an amount of 2-3 pieces above the permissible norm, can cause internal bleeding, and also lead to kidney failure. In medical practice, rare cases of anaphylactoid reactions, respiratory depression and coma due to an overdose of this drug have even been recorded.
If the permissible dose is already exceeded, it is not worth waiting for clinical manifestations. It is necessary to immediately wash the stomach, take an osmotic laxative and enterosorbents. It is advisable to go to the hospital after the above measures, where specialists will continue symptomatic treatment. It is worth noting that there is currently no specific antidote.
What do patients think of the drug?
Of course, in diseases with acute pain syndrome, almost all patients speak well of the medication we are considering. They note that the effect of the use of the drug occurs quite quickly, which is good news. Quite different comments can be heard when patients were prescribed a long course of therapy with Nimid. Tablets (the instruction recommends paying special attention to this pharmacological property of the drug) quickly relieve pain, but after a few days of taking, side effects make themselves felt. The first to react to nimesulide is the gastrointestinal tract, later the nervous system (this is manifested by irritability, a quick change in mood and a tendency to apathy).
Of course, it is impossible to say categorically that the medicine does more harm than good. After all, it really does help. But it is not recommended to take it without indications and the appointment of a specialist.
If, after the above information, there are doubts about whether to buy Nimid (tablets), instructions, patient reviews and consultation with the attending physician will help you make the right decision.
