Treatment of depressive processes is not complete without the use of antidepressants, which include the drug "Clofranil". The instruction recommends using it to eliminate various phobias, pain syndromes.
Medicine description
The active ingredient of the drug is clomipramine hydrochloride. It is produced by the Indian company Sun Pharmaceutical Industries in the form of blue round coated tablets.
The dosage of the drug is 0.025 g of clomipramine hydrochloride.
Mechanism of action
The drug "Clofranil" instructions for use refers to antidepressants with a tricyclic structure. With its participation, thymoanaleptic activity is carried out with a psychostimulating, anxiolytic, alpha-adrenergic inhibitory and sedative effect. The latter property is possible due to the relationship with H1-histamine receptors.
Different analgesic, histamine-blocking and antiserotonin effects. Eliminates spontaneous excretion of urine at night, suppresses the desire to eat.
Exhibits anticholinergic effects of a peripheral and central nature, caused by a strong attachment to choline-dependent receptor formations.
The drug "Clofranil" refers to antiarrhythmic drugs such as quinidine, blocking sodium channels. Therapeutic doses of clomipramine inhibit conduction in the ventricles of the heart.
Antidepressive activity occurs due to an increase in norepinephrine levels at the points of contact of neurons and serotonin content in the nervous system. These neurotransmitters accumulate due to the fact that the membranes of presynaptic neurons are less reuptake.
Prolonged use causes a decrease in functional activity in the serotonin-type and beta-adrenergic receptor formations located in the brain, contributes to the normalization of adrenergic and serotonergic transfer, and restores balance in systems that have been upset by depressive manifestations. Clofranil tablets help to cope with psychomotor retardation, depressed mood, anxious feeling.
Analgesic activity is manifested when the monoamine level changes in the parts of the central nervous system.
Anxiolytic action occurs with reduced excitation of the nucleus in the brainstem, which is regulated by the function of beta- and alpha2-adrenergic type receptors, as well as norepinephrine circulation.
Antidepressive activity is observed already 7 days after the start of treatment. Clomipraminecompared with imipramine, the psychostimulating effect is reduced, and when compared with amitriptyline, its sedative activity will be less pronounced.
Why take
Medication "Clofranil" instructions for use recommends using when feeling depressive of various developments, differing in certain symptoms.
The medicine is prescribed for a syndrome of depressive character, which accompanies schizophrenic manifestations, prolonged pain, bodily diseases and personality differences. They are treated with presenile and senile type processes, as well as their manifestations in childhood.
Drugs "Clofranil" instructions for use, the photo of which is presented below, indicates use in compulsive-obsessive disease associated with phobias, fears of panic, periodic pain in oncology, migraine, rheumatic disease.
It helps with post-herpetic nerve damage on the periphery, post-traumatic and peripheral neuropathy, narcolepsy, catalepsy. The drug is taken to prevent headaches and migraine attacks.
How to use
In the form of tablets, the Clofranil remedy is recommended for use when eating or after a meal to reduce irritation to the mucous membranes of the gastric wall.
Low dosage is used for therapy, these rules apply to people in the elderly and adolescence.
Depression, obsessive disease-compulsive and various phobias are treated with a dosage of 0.025 g for 3 doses per day. In the first week, the daily dose increases, from 0.100 to 0.150 g can be taken per day. If necessary, even larger doses are used. When the condition improves, they switch to maintenance therapy, which ranges from 0.050 to 0.100 g of the drug.
Narcolepsy with attacks of catalepsy is eliminated by tablets with a daily dose of 0.025 to 0.075 g of clomipramine. Chronic pain is treated with a daily dosage of 0.100 to 0.150 g, which is combined with concomitant analgesics, the number of the latter can be gradually reduced.
To eliminate attacks of fear, first use 0.010 g of the drug per day, which can be combined with a benzodiazepine. If the drug is well tolerated, then its amount is increased until positive changes appear. Then carry out a gradual abolition of benzodiazepine drugs. Treatment with the drug "Clofranil" instruction advises to cancel only six months later and not earlier. Over this period of time, a gradual reduction in maintenance dosing should be carried out.
In old age, therapy is prescribed with a daily dosage of 0.010 g. Then, for 10 days, the amount of the drug is increased to the optimal level, which ranges from 0.030 to 0.050 g. This dose is used throughout the therapy.
Unwanted consequences
Like all antidepressants, Clofranil can cause side effects. Anticholinergic effect is manifested by a fuzzy visual process, paresisaccommodative, dilated pupils, increased pressure inside the eye, increased contractions of the heart, dry mouth, confused mind, delirium, constipation, intestinal obstruction of a paralytic nature, difficulty urinating, small sweat.
Changes in the nervous system are characterized by a drowsy, asthenic process that causes disorientation, anxiety, agitation, restlessness, manic or hypomanic changes. Also, side effects are characterized by aggression, memory lapses, depersonalization, poor attention, insomnia, nightmares, asthenia.
Undesirable reactions of the heart and blood vessels are manifested by sinus elevation or changes in cardiac rhythm, orthostatic collapse, conduction failure inside the ventricles, pressure volatility.
Means "Clofranil" instructions for use describe changes in the digestive system, which are expressed by nausea, icteric hepatitis, heartburn, pain in the stomach, increased or decreased desire to eat, stomatitis, dental problems, changes in taste preferences, blackening tongue surface.
Hormonal disorders are characterized by swelling of the testicles, proliferation of mammary glands in males and an increase in women, an excessive dose of prolactin, galactorrhea, low or high sexual desire, deterioration in potency, hyper- or hypoglycemia, hyponatremia, inadequate secretion of antidiuretic hormone.
Changing the work of hematopoieticorgans is associated with a decrease in the number of leukocyte and platelet blood cells, purpura, an increase in the number of eosinophils.
An allergic reaction may occur in the form of a skin rash with itching, fear of ultraviolet radiation, angioedema.
Side effects include hair loss on the head, petechiae, feeling warm or cold, urinary retention or increased frequency, low blood proteins, fever and high fever.
As a result of the sudden withdrawal of the drug, nausea, vomiting, indigestion, headaches, malaise, insomnia, dreams may occur. Gradually reducing the dose of the drug can make a person irritable, cause a state of motor restlessness.
Children
Obsessive-compulsive syndrome is treated with an initial dosage of 0.0125 g. For 14 days, a gradual increase in concentration is carried out, taking into account the tolerability of the drug. The daily dose after 2 weeks is equal to 0.100 g or it is calculated by the weight of the child, when for every 1 kg of weight there is 0.003 g of the active substance. The next 14 days are accompanied by a gradual increase in the concentration of the drug to 0.200 g or recalculation by weight.
The appointment of Clofranil for children deserves a positive review in the treatment of nocturnal enuresis. Initial therapy is carried out with a daily dose of 0.020-0.030 g for the age of 5 to 8 years, for adolescents from 9 to 12 years old, 0.025-0.050 g is used; after 12 yearsdesignate 0.025-0.075
Increase in dosage is carried out by patients who did not help the medicine at all 7 days after therapy. The entire daily dose of the drug is prescribed to drink in one application in the evening after meals. With involuntary urination in the evening during sleep, half the dosage is prescribed to drink up to 17 hours. When the desired effect is achieved, the drug is not withdrawn for about 90 days, during which a gradual decrease in the level of the drug is carried out.
Clofranil medicine, analogues
There are many clomipramine hydrochloride preparations that are considered interchangeable.
One of these drugs is the Italian drug Anafranil, which is produced by Novartis Pharma. It is also referred to as tricyclic antidepressants. This psychotropic drug is used to treat depressive processes and mental disorders. The preparations "Clofranil" and "Anafranil" contain the active ingredient clomipramine in the form of a hydrochloride s alt.
The drug is available in the form of regular and extended release tablets. Its simple dosage is 0.025 g, and the retard includes 0.075 g of the active ingredient. Regular tablets have a light yellow sugar shell. The prolonged form of the drug contains a pink coating.
There is a liquid type of medicine, which is represented by a solution for intramuscular and intravenous administration of 2 ml. The dosage of the injection drug "Anafranil" is 0.025 gclomipramine hydrochloride, which is dissolved in sterile water and glycerin.
Another similar drug is Clomipramine, which comes in the form of tablets for oral use. To protect the mucous membrane of the digestive system, they are coated. The dosage is 0.025 g of clomipramine hydrochloride. To designate it, “25” is stamped on each tablet. The action of the drug is aimed at combating depression. The drug is dominated by psychostimulating, thymoleptic and sedative activity. The latter function is associated with blocking the reuptake of neuronal serotonin molecules, which improve the mood of the patient.
It is used for the treatment of depressive processes, which are caused by various reasons. The drug is well treated with psychopathy, schizophrenia, phobias, panic disorders of an obsessive-compulsive nature, cataplexy, narcolepsy. Children after 5 years of age are prescribed to eliminate bedwetting.
In the drug "Clofranil" analogues may contain an active substance other than clomipramine hydrochloride. For example, the drug "Soneks" in its composition has the active ingredient zopiclone, which is contained in a single dose of 0.0075 g. The drug causes the onset of sleep, has a calming, anticonvulsant and muscle relaxant effect. The common quality of Clofranil and Sonex is their sedative property.
Produced by the Belarusian pharmaceutical company Rubicon LLC in the form of round, biconvex tablets with whiteshell coating and a risk for halving. It is used to treat severe sleep disorders, with situational and temporary insomnia.
Drug "Truxal"
Considered to be another similar analogue based on chlorprothixene hydrochloride, which is a thioxanthene derivative. Produced by the Danish company AO Lundbeck. The drug belongs to antipsychotic drugs that have antipsychotic, pronounced sedative and moderate antidepressant activity.
There are four dosages of medication: 0.005, 0.015, 0.025 and 0.050 grams. The first three doses are available as brown, biconvex and round shell-coated tablet units. The highest dose is presented as an oval tablet with biconvex surfaces.
Antipsychotic activity is carried out due to the inhibition of dopamine receptor formations. With the blockade of these areas, the antiemetic and analgesic effect of the drug occurs. The drug inhibits 5-HT2-receptor associations, α1-adreno- and H1-histamine-dependent receptors, which causes adrenoblocking, antihistamine activity.
The drug is classified as an antipsychotic drug with a sedative effect, which is intended for the treatment of psychotic, schizophrenic and crazy attacks.
It is used to eliminate children's behavioral deviations, to overcome hangover withdrawal symptoms in alcohol and drug addiction, to combat hyperactivity, irritable process, confused consciousness in senileaged.
The drug is effective in depressive changes, insomnia, neurosis.
Together with the analgesic drug, Truxal eliminates painful processes.
Comparison of Clofranil with analogues
The closest in action and composition is the drug "Anafranil" in the form of regular release tablets. Dosage forms of retard with a dosage of 0.075 grams and a solution for intramuscular and intravenous use cannot be compared with the Indian antidepressant, as it is not available in this form.
Many patients are tormented by the question: what is the difference between Clofranil and Anafranil? First of all, there is a difference in the composition of inactive ingredients. The presence in the Indian drug of brilliant blue, sodium carboxymethyl starch, hypromellose 2910, macrogol 6000, which are not in the Italian drug, indicates the difference between the two analogues. These ingredients in the Anafranil tablets were replaced with stearic acid, glycerol 85%, hydroxypropyl methylcellulose, a copolymer of vinylpyrrolidone and vinyl acetate, crystalline sucrose, polyvinylpyrrolidone K30, yellow iron oxide 5%, titanium dioxide, macrogol 8000.
The presence of milk sugar in both preparations enhances the bioavailability of the active substance. However, the presence of lactose makes them unsuitable for people who are lactose intolerant.
Different auxiliary ingredients of the two analogues change the strength of penetration, absorption,effects and excretion of clomipramine hydrochloride from the body. They are also responsible for the development of all kinds of side effects. The difference between Anafranil and Clofranil is related to the price. The Italian drug costs a little more than the Indian counterpart.
If we compare which is stronger: "Truxal" or "Clofranil", then it is believed that the first drug has a stronger sedative, sedative and inhibitory effect, which allows you to overcome various psychotic disorders.
According to the mechanism of influence, antipsychotics are very different from antidepressant drugs. The action of the drug "Truxan" is aimed at suppressing pathological mental activity, at reducing the work of neurotransmitter substances. With the help of the drug "Clofranil" their function is enhanced and stimulated.
The release of dopamine is suppressed by antipsychotics, and exposure to antidepressants enhances the production of this substance.
Patient opinions
About the drug "Clofranil" reviews can be heard different. For many depressed patients, this remedy helped to get rid of negative and obsessive thoughts, there was joy in life.
Other people were prescribed the drug for alcoholism with severe psychological dependence. After a course of medication, the patient returned to an adequate, calm, balanced state, aggression disappears.
On the drug "Clofranil" instructions for use reviews contain both positive and negative. This is due to the fact that inThe section "Adverse reactions" contains a huge list of undesirable consequences that may occur during treatment. In practice, many doctors note the good tolerance of this drug, the main thing is to choose the right dose and adjust it in time if necessary.
Positive reviews on Clofranil are associated with the manifestation of its effectiveness in a timely manner, which are declared by the manufacturer of the medicine. Also pleased with its availability in financial terms. The drug begins to act after one week from the start of use, which is very important for relieving an acute attack of the disease.
The disadvantage is that the treatment with the drug cannot be stopped immediately, but a gradual decrease in dosage is required.
Patients with panic disorder experience increased anxiety in the early stages of therapy. Such a paradoxical feature appears during the first day, and then decreases after two weeks.
