High plasma cholesterol contributes to the development of atherosclerosis and heart disease.
For lipid-lowering treatment, special means are used, one of which is the drug "Atocor". The instructions for this medication describe its hypocholesterolemic and hypotriglyceridemic role in reducing the concentration of bad cholesterol and other fats in the human body.
General characteristics
The drug belongs to inhibitors of 3-methylglutaryl-3-hydroxy-coenzyme A reductase. Produced by the Indian company "Doctor Reddy's Laboratories".
Atokor can have dosages of 0.020 and 0.010 g.
Issue form
The product is produced in tablet form with a white film coating. The tablets are extruded in the shape of a triangle with biconvex surfaces, on one of which the letter “A” is applied, and on the other there is a dose designation of “10” or “20”.
Composition
The active ingredient of the drug is atorvastatin, which is represented by micronized calciumtrihydrate. The dosage and composition of the quantitative active ingredient of the drug "Atokor" are slightly different. Each 0.01084 or 0.02168 g of atorvastatin calcium trihydrate is equivalent to 0.01 or 0.02 g of pure atorvastatin.
Milk sugar, calcium carbonate, croscarmellose sodium, polysorbate 80, hydroxypropyl cellulose, lactose DT, magnesium stearate form the tablet structure.
The film shell is formed from hypromellose 15 cps, propylene glycol, purified talc, titanium dioxide.
The composition is the same for both dosages of Atokor, and they have a common instruction.
Tablets of 0.01 or 0.02 g are available in blister packs of 10 packed in a carton box.
Mechanism of action
Drug instructions for use refer to selective, competitive inhibitors of 3-methylglutaryl-3-hydroxy-coenzyme A reductase. It is an important enzymatic compound for the conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonic acid, which is the precursor to styrenes and cholesterol.
If patients have homozygous, heterozygous familial and non-familial hypercholesterolemia, as well as mixed dyslipidemia, then taking Atocor helps to reduce the concentration of total cholesterol, cholesterol particles found in low and very low density lipoproteins, triglycerides and apolipoprotein B.
Medication "Atokor" description of the drug indicates the ability of tablets to unstable increase the level of useful sterol inhigh density lipoproteins.
In liver cells, triglyceride and cholesterol molecules become an integral part of lipoprotein substances, which have a very low density. They go to the plasma, with which they penetrate into the peripheral tissue. They form lipoprotein compounds with low saturation, which can be catalyzed by interaction with high-affinity receptor formations. All these substances can enhance the development of atherosclerosis.
The action of atorvastatin is characterized by a pronounced and persistent increase in the effectiveness of LDL-receptor complexes, a decrease in the concentration of harmful cholesterol with increased cholesterolemia of a homozygous hereditary species.
Means "Atokor" instruction indicates its ability to reduce plasma levels of cholesterol and lipoprotein by inhibiting HMG-CoA reductase enzyme. It slows down the formation of cholesterol in the liver cells, increases the number of receptor formations of lipoproteins with low saturation in cell membranes. This enhances the uptake and catabolism of cholesterol molecules from low concentration lipoproteins.
What is used for
Medication "Atocor" instructions for use of the tablet advises taking with the primary signs of increased cholesterolemia of the heterozygous type, local and non-local increase in cholesterol concentration, mixed heterolipidemia, increased amount of plasma triglyceride molecules.
They are prescribed in combination with dietaryprescriptions for lowering high cholesterol levels in low saturation lipoproteins, apolipoprotein B and triglyceride compounds.
Pills reduce plasma LDL cholesterol concentrations in homozygous familial elevated cholesterolemia when dietary nutrition and other non-pharmacological methods are ineffective.
How to take
Medication "Atokor" instructions for use recommends drinking only after prescribing a standard hypocholesterolemic diet to a sick person, which should be used in the course of therapy. Dosing is set for each patient separately, which is calculated from the initial level of cholesterol in low saturation lipoproteins. It is important to take into account the intended purpose, the effectiveness of therapy with Atocor, indications.
Typically, the initial dosage is 0.010 g per dose per day. The use of tablets does not depend on the time of day and the consumption of food.
The daily dosage of the remedy from 0.010 to 0.080 g is selected taking into account the initial indicators of harmful cholesterol, target prerequisites and personal effectiveness. At the initial stage of use and with an increase in the concentration of the drug, the level of plasma fats should be checked after half a month, and if necessary, adjust the dose.
Primary hypercholesterolemia and combined hyperlipidemia are treated with a daily dosage of 0.010 g.
Therapeutic activity occurs after 14 days, and maximum effectiveness is possible after onemonth. Long-term use allows you to maintain the therapeutic effect.
Drugs "Atokor" instruction in Russian contains information about the treatment of hypercholesterolemia by homozygous family type. Usually, a daily dosage of 0.080 g is prescribed. With this use, the cholesterol value in LDL decreases to 40%.
Features of treatment
On Atokor tablets, the instructions for use strongly recommend that before you start using the drug, you should find the cause of the secondary increase in cholesterol values. These factors include poor therapy for diabetes mellitus, hypothyroidism, nephrotic process, dysproteinemic changes, obstructive liver disease. This can also include treatment with other drugs and alcohol dependence. Only after getting rid of the above reasons, you can start using Atocor tablets.
Even before therapy, the lipid balance between total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides is determined.
There is no data on the use of the drug in pediatric practice, therefore these pills are not prescribed to children.
In the treatment of elderly patients over 60 years of age, there is an increase in the plasma level of the active ingredient of the drug up to 40%.
If renal function is impaired, no dose adjustment is necessary, as this condition does not affect atorvastatin levels in the bloodstream and the effectiveness of lowering bad cholesterol.
There is evidence that drug useof this class cause the development of rhabdomyolysis myopathy and insufficient kidney function in an acute form. With such diseases, the medication should be abandoned for a while.
Atorvastatin-based drugs should be taken with caution in people who abuse alcohol or have a history of liver disease.
Under the action of inhibitors of the HMG-CoA reductase enzyme, changes in the biochemical parameters of the liver are possible. For the timely detection of such disorders, it is necessary to evaluate the liver activity before treatment, and then 3 months after taking the pills, re-check.
Medication "Atocor" instruction in Russian includes information about a marked increase in the plasma value of the active ingredient in patients with hepatic diseases who suffer from alcoholism. Temporary or complete refusal of therapy returns the transaminase activity of the liver to its original limits. Many patients did not cancel the use of the drug in small doses, and no adverse reactions occurred.
Treatment may cause dizziness, drowsiness may develop, so patients are prohibited from driving vehicles or other complex devices while taking the tablets.
Who should not use
Contraindications for the drug "Atokor" include hypersensitivity to each ingredient of the drug.
It is not taken in acute liver diseases and with high activation of transaminase serum enzymes, whentheir activity is 3 times higher than the value of the upper limit of normal indicators.
The drug is not prescribed to women of reproductive age who do not use adequate contraceptives. Contraindication is the state of childbearing and breastfeeding.
The medicine does not treat children and adolescents under 18 years of age.
Due to the presence of milk sugar in the composition of Atocor tablets, the instructions for use prohibit their use in case of hereditary intolerance to galactose molecules, with a lack of lactase and malabsorption of galactose-glucose.
Analogues
There are a large number of drugs based on atorvastatin. The hypocholesterolemic role is assigned to the preparation "Atocor" instructions for use. Analogues are also able to lower the level of bad cholesterol in human blood.
One of these medicines is the Slovenian medicine "Atoris", the manufacturer of which is the joint-stock company "Krka, Novo mesto". Available in the form of tablets containing the active ingredient of 0.010 g, 0.020 g, 0.040 g.
The drug is intended to eliminate the hyperlipidemic condition, in which it is necessary to reduce total cholesterol, cholesterol in lipoprotein compounds with low saturation, the number of apolipoprotein and triglyceride molecules in the bloodstream.
The drug is used to treat people with hypercholesterolemia of the polygenic, heterozygous homozygous familial type.
With helpdrugs "Atoris" increases the concentration of cholesterol in lipoproteins with high saturation.
Another Slovenian analogue is the Tulip drug, which is produced by the Lek Pharmaceutical Company. Film-coated tablets are available in three strengths: 0.01g, 0.02g and 0.04g each.
The drug is prescribed to eliminate the primary form of hypercholesterolemic and combined hyperlipidemic state, for the treatment of high cholesterol heterozygous and homozygous family type.
A similar remedy is the Indian medicine "Astin", which is produced by the company "Micro Labs Limited". Available in two doses: 0.010 g and 0.020 g of atorvastatin.
The drug is prescribed for elevated lipid levels, when there is no positive effect from dietary nutrition and other activities.
Indian production is the drug "Storvas" based on the calcium s alt of atorvastatin. Produced by Ranbaxy Laboratories Limited in the form of a coated tablet in two dosages: 0.010 g and 0.020 g each.
The drug "Storvas" reduces the increased content of total cholesterol, cholesterol molecules in LDL, the concentration of apolipoprotein and triglyceride compounds in the primary, heterozygous familial and non-familial hypercholesterolemic state, as well as in mixed hyperlipidemic disease.
The drug reduces the possibility of developing a heart attack of the myocardial muscle, strokes and changes in the braincirculation. Tablets slow down the progression of coronary atherosclerosis.
The American analogue is the drug "Liprimar", which is produced by the company "Pfizer". Available in the form of coated tablets in three dosages: 0.010 g, 0.020 g, 0.040 g each. The drug is also used to eliminate the hypercholesterolemic state of various types of origin.
Reviews
Medicine "Atokor" instructions for use characterizes as a tool with high proven efficiency. Many patients suffering from elevated plasma levels of harmful cholesterol feel better after a course of use. The values of total cholesterol, as well as LDL, are reduced to a normal level, which reduces the likelihood of developing an atherosclerotic and ischemic condition.
The drug is well tolerated, but in some patients it can cause stool retention, bloating, pain in the abdomen, nausea, and indigestion. There are headaches, sleep is disturbed. A convulsive, asthenic and myalgic condition may develop.
In rare cases, side effects are manifested by myositis, myopathy, paresthesia, peripheral neuropathy, pancreatitis, hepatitis, cholestatic jaundice.
Pills may cause anorexia, vomiting, hepatotoxicity, alopecia, pruritic rash, impotence, cataracts, hyper- or hypoglycaemia.
