A number of pathologies are characterized by increased formation of urates and their deposition in tissues. "Allopurinol" is a drug that reduces their number. When should the medicine be used and what can be replaced with it?
Action
The drug helps to reduce the activity of xanthine oxidase, that is, it inhibits it. As a result, the formation of urates is reduced, since the enzyme is necessary for the conversion of hypoxanthine to xanthine and its further transformation into uric acid. That is why the s alts of this substance are not produced in excess and are not deposited in the tissues. This is how Allopurinol works. The analogues listed below have the same mechanism.
When is the drug used?
"Allopurinol" is necessary for diseases that are associated with metabolic disorders. This group primarily includes pathologies of the urinary system, accompanied by hyperuricemia, but among the indications there are other diseases. For example, excessive formation of urates is observed with increased breakdown of nucleotides, which often has a medicinal genesis. The drug is prescribed for the following pathological conditions:
- Urolithiasis with urate formation;
- gout;
- treatment of tumor conditions;
- long-term corticosteroid treatment;
- traumatic toxicosis;
- pathologies of purine metabolism;
- psoriasis;
- Cider Lesha - Nihena.
In these diseases, doctors prescribe "Allopurinol", analogues. Drug prices vary.
Can everyone take the medicine?
The drug has a serious impact on metabolic processes, so it is not without contraindications. You can not take it in the presence of hypersensitivity, which will lead to allergic conditions. Also, the drug is contraindicated in renal failure, which is in the stage of azotemia; pregnancy and lactation, idiopathic hemochromatosis, acute manifestations of gout (an attack should be stopped before taking).
At the age of 14 years, the drug is prescribed only if there are significant indications, while taking the medicine should be strictly controlled by a doctor. In addition, it should be taken with caution if there is heart failure, hypertension, or diabetes mellitus. This list is typical for the drug "Allopurinol". Analogues also have contraindications. We will talk about the synonyms of the drug a little later.
"Allopurinol": instructions for use
Analogues will be discussed below, but for now let's talk about how to take Allopurinol. The use of the drug is allowed only under the supervision of a specialist, sincecareful individual selection of a dosage is required. During treatment, monitoring of serum uric acid levels is necessary. The amount of active substance depends on the degree of the disease. With a mild course, as a rule, 100-200 mg per day are prescribed, and with an average dose, the dose is doubled. Severe pathologies usually require 700-900 mg per day. For children, the dosage is selected based on body weight. The effect of the drug is observed 24-48 hours after administration. Price - 120 rubles for 30 tablets.
Combining with other substances
Another factor that does not allow self-medication is the presence of pathological reactions when combined with certain drugs. "Allopurinol" can not be taken simultaneously with "Azathioprine", "Methotrexate", "Theophylline", mercaptopurines, as the toxicity of the latter increases. Also, the drug is able to enhance the anticoagulant abilities of indirect anticoagulants and the hypoglycemic effect of Chlorpropamide. Combination with "Amoxicillin" and "Ampicillin" can provoke the appearance of a skin rash. Before prescribing, you should find out what drugs the patient is taking, and only then proceed with treatment.
"Allopurinol": analogues, synonyms
The drug has the following analogues: "Allopurinol-Egis", "Sanfipurol", "Purinol", "Allupol". The effect of the drugs is similar, but they have some differences. It is not always possible to purchase Allopurinol. Analogues, the price of which may bebelow, solve the problem.
Alopron
The medicine can be used in pregnant women, but only if there are strict indications for treatment. In this case, the dosage should be selected more carefully. If it is necessary to prescribe the drug during lactation, you should stop feeding and temporarily switch to artificial nutrition. Therapy begins with the appointment of a reduced dose - 100 mg. After 1-3 weeks, it is increased to 300 mg. For children, the dosage is calculated based on body weight.
Allopurinol-Egis
The medicine, unlike the hero of the article, can be used with almost no restrictions in childhood. It is prescribed orally, the dosage is selected taking into account individual characteristics. As a rule, 200-400 mg per day are required, but the dose can be increased if necessary. Children should use a smaller amount of the drug, and the daily portion is divided into three doses. Cost - 100-110 rubles.
Elevated levels of uric acid in the blood is fraught with the deposition of urates in the tissues, mainly affecting the kidneys. Taking hypouricemic drugs, which include Allopurinol (analogues can also be used), helps prevent such consequences.
