Metrogil (intravenously) refers to antimicrobial and antiprotozoal drugs. The active substance of the drug is metronidazole. The drug shows its activity against a number of gram-positive bacteria, obligate anaerobes. In combination with amoxicillin, it acts on Helicobacter pylori. Resistance to the drug is shown by facultative anaerobes, aerobic microorganisms. The drug increases the sensitivity to radiation of tumors, provokes disulfiram-like manifestations, stimulates repair processes.
Metrogil medicine (for intravenous administration). Pharmacokinetics
When infused with 500 mg for 20 minutes, the maximum content of the drug in the blood is observed after an hour. About 30-60% of the drug is metabolized. The main metabolite has an antimicrobial and antiprotozoal effect. About 60-80% is excreted in the urine, up to 15% of the drug is excreted in the feces.
Destination
The drug is indicated for the treatment and prevention of infectious lesions caused by susceptible microbes. In particular, a medicine is recommended for surgical interventions in the urinary tract.tract and on the organs of the abdominal cavity. Indications include sepsis, severe hepatic and intestinal amoebiasis, osteomyelitis, abscesses of the brain, small pelvis. The drug "Metrogil" is prescribed (intravenously) for lesions of soft tissues, skin, bones, joint infections, gynecological pathologies. The drug is recommended for radiation therapy of tumors (as a radiosensitizing agent in cases of neoplasm resistance due to hypoxia in its cells).
Application diagram
The initial dosage for patients from 12 years old is from half to one gram drip. The duration of the infusion is thirty to forty minutes. Every subsequent 8 hours, the drug is administered at 500 mg. The infusion rate is 5 ml/min. With satisfactory tolerance after the first 2-3 infusions, jet administration is used. The duration of therapy is a week. No more than 4 g is allowed per day. For patients under 12 years of age, the drug "Metrogyl" (intravenously) is prescribed according to the indicated scheme in a single dosage of seven and a half milligrams / kg. For the prevention of complications during surgical interventions, patients from 12 years of age are prescribed before surgery from 0.5 to 1 g on the day of the operation and the next day, 1.5 g / day. (0.5 mg every 8 hours). When used as a radiosensitizing agent, the administration is carried out by drip at 160 mg/kg or from 4 to 6 g/m2 of the body surface. The infusion is given half an hour to an hour before irradiation.
Side effect of the drug "Metrogyl" (intravenously). Reviews
As practice shows, whencompliance with the infusion rate and dosing regimen, undesirable effects rarely develop. According to the observations of specialists, patients satisfactorily tolerate therapy. Rarely, there may be disturbances in the activity of the gastrointestinal tract, the nervous system. On the basis of hypersensitivity, the development of an allergic reaction is likely. Some patients experienced convulsions, hallucinations, loss of appetite, taste of metal in the mouth.
