Mydocalm-Richter is an effective modern muscle relaxant designed to relieve pain of various etiologies and localizations. The drug is available in tablet and injectable form for parenteral use under the name Mydocalm-Richter (injections). Reviews of many patients allow us to conclude that the drug is very effective in reducing muscle hypertonicity. The drug has an effect on the central nervous system, so it is not recommended to take it without a doctor's prescription. Today, many readers are interested in the question of what is Mydocalm-Richter (injections)? Instructions for its use, indications and contraindications for use are described below.
Biochemical composition of the drug
The composition of the drug includes a complex of biologically active and excipients:
- tolperisone hydrochloride (bioactive compound);
- lidocainehydrochloride;
- diethylene glycol monoethyl ether;
- injectable water;
- methylparaben.
Pharmacodynamics
The exact mechanism of action of the drug "Mydocalm-Richter" (injections) on the human body has not yet been deciphered. Scientists suggest that due to the effect of the drug on afferent fibers, poly- and monosynaptic reflexes of the spinal cord are blocked. The bioactive components of "Mydocalm-Richter" inhibit the release of the transmitter by blocking the entry of Ca2+ ions into synapses. Tolperisone hydrochloride exhibits a weak antispasmodic and adrenoceptor blocking effect. And that's not all for the drug "Mydocalm-Richter" indications for use. It activates peripheral blood circulation, improves the metabolism of substances in the pathological zone.
Pharmacokinetics
After oral use, the drug is well adsorbed by the mucous membrane of the small intestine. The maximum concentration in the patient's blood is observed after half an hour, the bioavailability during oral use of the drug is about 20%. Tolperisone hydrochloride is metabolized in the tissues of the liver and kidneys. Excretion of metabolites occurs mainly through the kidneys.
"Mydocalm-Richter": instructions for use
Given the pharmacodynamics of the drug, it is prescribed for many pathologies associated with hypertonicity of muscle fibers. Most experts recommend starting treatment with injections, and then moving on to taking the tablet form of the drug. Such a treatment regimen guarantees a quick recovery of the patient. The medication is prescribed for the following pathologies:
- encephalopathy;
- ischemic stroke;
- thrombophlebitis of the lower extremities;
- diabetic angiopathy;
- myasthenia gravis of central origin;
- encephalitis;
- obliterating endarteritis;
- psorioid arthritis;
- deforming osteoarthritis;
- pain syndrome provoked by osteochondrosis or sciatica;
- muscle dystonia;
- lumbago;
- menstrual pain;
- Little's disease in children;
- intervertebral hernia;
- rheumatoid arthritis;
- renal colic;
- hemorrhoids;
- vascular sclerosis;
- spondyloarthritis;
- gallstone disease;
- threat of miscarriage due to myometrial hypertonicity;
- autoimmune pathologies (Raynaud's syndrome, systemic scleroderma, etc.);
- vascular sclerosis;
- acrocyanosis.
Contraindications
If you decide to use Mydocalm-Richter (injections), the instructions for use indicate that this medicine should not be used in the following cases:
- the period of childbearing and breastfeeding;
- myasthenia gravis in severe form;
- age category under 18;
- hypersensitivity to drug ingredients.
Main analogues of the drug
The modern pharmaceutical market is famous for its wide range of medicines. For almost every drug, you can choose an analogue that is similar in mechanism of action. Mydocalm was no exception - a mega-popular medicine, of which there are many analogues:
- "Sirdalud";
- "Tolperison";
- "Tolperil";
- Mefidol;
- "Liorezal";
- "Miolgin";
- Baclofen.
Before replacing Mydocalm-Richter (the instruction warns about this), you need to consult with your doctor, since only he can make a qualified selection of this or that medication.
Surdalud
One of the most popular analogues of Mydokalma. This is a potent remedy that can be taken once a day, it effectively stops even the most severe pain. When taking the drug, you should be aware that it can cause excessive fatigue and drowsiness.
Tolperison
The presented drug belongs to the muscle relaxants of the central action. It is often prescribed for the treatment of muscle hypertonicity, obliterating vascular diseases. This product is about half the price of the original.
Miolgin
Analgesic and antipyretic effect of the drug due to the presence of paracetamol in its composition. Miolgin is prescribed for neuralgia, sprains and muscle strains. This is a fairly effective drug for headaches. Most experts do not recommend taking this medicine to patients under the age of 18.age, lactating mothers and pregnant women.
Baclofen
This remedy is reserved for extreme cases as it has a number of side effects. It is important to remember that when choosing one or another analogue of the drug, just reading the instructions for use is not enough. You need to choose a medication very carefully, strictly following the instructions of your doctor.
Side effects
Does a drug like Mydocalm-Richter have side effects? Instructions for use does not exclude the development of side effects. This is:
- allergy;
- nausea;
- anorexia;
- fatigue;
- skin itching;
- vomit;
- flatulence, diarrhea;
- loss of balance, tinnitus;
- intense thirst;
- arterial hypotension;
- appearance of a feeling of intoxication;
- Quincke's edema;
- severe pain in limbs;
- dyspeptic and dyspeptic disorders;
- muscle weakness;
- headache;
- nosebleed;
- erymatous rashes;
- tachycardia;
- skin hyperemia;
- shortness of breath, shortness of breath;
- rarely anaphylactic shock;
- osteopenia;
- excessive sleepiness;
- reduced physical activity;
- depression;
- increased blood creatinine levels;
- violation of the activity of liver transaminases (AST, ALT);
- vision disorders.
Drug overdose
There are not so many data on an overdose of Mydocalm-Richter. The drug is characterized by a broad therapeutic index. Preclinical studies have shown that the following symptoms are observed when the drug is administered at doses significantly higher than recommended, therapeutic:
- ataxia;
- shortness of breath (to the point of stopping);
- tonic seizures.
It is worth noting that there are no specific antidotes that neutralize the action of tolperisone hydrochloride. In case of an overdose, immediate medical assistance is indicated (gastric lavage). Symptomatic and supportive therapy is shown below.
Interaction with other drugs
There are no studies on the compatibility of Mydocalm with other medicines, so the solution should not be mixed in the same syringe with other medicines before administration.
The use of "Mydocalm-Richter" is allowed with sedatives, hypnotics, and ethanol-containing drugs. If necessary, it can be used in conjunction with other muscle relaxants, but in this case, the daily dose of the bioactive substance will need to be reduced.
"Mydocalm" enhances the effect of niflumic acid, as well as other NSAIDs, because of which the dose of the latter, when taken in combination with the indicated medication, will need to be reduced. The pharmacological action of Mydocalm is enhanced by the following medications:
- clonidine;
- muscle relaxersperipheral action;
- drugs used for general anesthesia;
- psychotropic drugs.
"Mydocalm-Richter" (injections) reviews
Many people are interested in the question of what Mydocalm really is. Instructions for use, the cost of the medicine, indications and contraindications are, of course, the main criteria for evaluating the drug. Nevertheless, it is worth getting acquainted with the opinion of doctors and patients on this matter. There is an opinion among doctors that Mydocalm-Richter is one of the best modern muscle relaxants. Patient reviews in this case coincide with the opinion of specialists, since the drug is characterized by high efficiency, good tolerance and reliable relief of pain of various localization and etiology. In most cases (from 85 to 95%), the reviews about the drug are positive. You can find rare negative reviews that indicate that treatment with the indicated medication is not effective enough. The drug "Mydocalm-Richter", the indications for the use of which were considered in this article, is released strictly by prescription. In case of any complications, the patient should consult a doctor.
