Combiflox is an excellent drug for fighting parasites and microbes that live in the human body. The drug has a wide range of effects. Most often it is used in the presence of mixed infectious pathologies that are bacterial in nature. But some patients, for various reasons, cannot resort to the help of the original remedy. Naturally, they have many questions. What analogues can be taken? "Combiflox" and its substitutes have the same efficiency? Let's figure it out.
Brief characteristics of the drug "Combiflox"
The drug is an excellent antimicrobial and antiprotozoal agent with antibacterial activity. The combined medicine is prescribed for a wide variety of infectious ailments.
Its wide range of effects is dictated by the components that make up the drug:
- Ornidazole. This substance has antimicrobial and antiprotozoal effects. The component is a derivative of 5-nitroimidazole. The substance, getting into the human body, affects the DNA of pathogenic microorganisms. As a result, the bacteria die. The ingredient actively fights against a variety of microorganisms. But it remains insensitive to aerobic.
- Ofloxacin. An antimicrobial substance that is part of the fluoroquinolone group. Its mechanism of action is associated with the effect on DNA gyrase (a bacterial enzyme). The component provides destabilization of DNA chains. Such exposure leads to the death of bacteria. The substance has a pronounced bactericidal effect.
The drug is produced in the form of film-coated tablets.
Indications for prescription
What is Combiflox medicine for? The medication instruction recommends taking the pills at:
- Bacterial mixed infections caused by susceptible microorganisms.
- Infectious and inflammatory diseases of the peritoneum, kidneys (pyelonephritis), biliary tract.
- Diseases of the reproductive system and pelvic organs (endometritis, oophoritis, salpingitis, cervicitis, parametritis, colpitis, orchitis, prostatitis, epididymitis).
- Infectious diseases of the urinary tract (urethritis, cystitis).
Contraindications for taking
Treatment restrictions should be carefully considered before using this drug in therapy.
Combiflox tablets -instructions for use prohibits use by people under the following conditions and pathologies:
- individual hypersensitivity;
- epilepsy;
- age, under 18;
- reduced seizure threshold (triggered by TBI, strokes, CNS inflammation);
- pregnancy;
- tendon injury during fluoroquinol therapy;
- lactation period.
Special Instructions
The drug is prescribed with great care to patients suffering from:
- atherosclerosis;
- impaired cerebral circulation;
- kidney failure;
- liver disease;
- organic pathologies of the central nervous system (multiple sclerosis);
- predisposition to convulsive manifestations;
- myasthenia gravis;
- diabetes;
- heart disease (heart attack, heart failure, bradycardia);
- history of various mental disorders;
- alcoholism.
Side effects
The medicine can become a source of numerous unpleasant reactions. That is why this medication should be prescribed exclusively by a doctor who will control the treatment process. So, what kind of reactions can patients who use Combiflox tablets experience?
The instruction warns of the possible occurrence of the following side effects:
- Digestive system. Gastralgia, nausea, vomiting may occur. Sometimes appetite decreases, diarrhea appears orconstipation. Patients may experience abdominal pain, increased flatulence, hepatitis, cholestatic jaundice, pseudomembranous colitis. Many complain of increased dryness of the mouth.
- Nervous system. Therapy may be accompanied by dizziness, high nervousness, insomnia, headache. Sometimes there is a tremor, paresthesia or numbness of the limbs, convulsions, uncertainty in movements. The patient may have nightmares. Some patients develop phobias, depression, hallucinations. Perhaps the appearance of epileptic seizures, psychotic disorders with a predisposition to suicide.
- The musculoskeletal system. It is impossible to exclude the risk of developing tenosynovitis, tendonitis, arthralgia, myalgia in a patient. Sometimes during treatment, pain in the limbs, muscle weakness, and tendon ruptures are diagnosed.
- Sense organs. The patient may experience a violation of taste, smell. Sometimes failures occur with coordination or hearing. Some patients report a violation of color perception or strange taste sensations.
- The cardiac system. Periodically, patients suffer from tachycardia. Some note an increase or, conversely, a decrease in pressure. Possible collapse, ventricular arrhythmia. Sometimes there is a prolongation of the QT interval.
- Allergy. Treatment may be accompanied by the appearance of urticaria, itching, and an unpleasant skin rash. In some cases, there is the development of allergic pneumonitis, nephritis, angioedema, fever, bronchospasm, eosinophilia. Exudative erythema may appearepidermal toxic necrolysis, anaphylactic shock, photosensitivity, vasculitis. Women may experience increased itching in the genital area.
- Hematopoietic organs. During therapy, the development of leukopenia, anemia is sometimes noted. Some face thrombocytopenia, agranulocytosis.
- The urinary system. Sometimes patients complain of impaired renal function, dysuria, urinary retention. Against the background of treatment, the concentration of urea may increase, kidney failure may develop.
In addition to the above unpleasant manifestations, the appearance of:
- intestinal dysbacteriosis;
- superinfection;
- hypoglycemia;
- vaginitis;
- chest pain;
- fatigue;
- nosebleeds;
- strong thirst;
- pharyngitis;
- rhinitis;
- dry cough.
Best analogues
What drugs can replace the original remedy? On the pharmacological market, there are the following analogues of Combiflox
:
- "Ashof" (solution);
- "Dancil" (drops);
- Gyro (tablets);
- "Zanocin" (solution, tablets);
- Dazolic (tablets);
- Zoflox (solution, tablets);
- Ornidazole (tablets);
- Lornizol (pills);
- Orniona (tablets);
- Oflo (pills);
- "Ornisid" (tablets);
- Ofloxabol (solution);
- Oflox (tablets);
- Ofloxacin(tablets, solution, ointment);
- "Tarivid" (solution);
- Taricin (tablets);
- Tiberal (pills);
- "Floxal" (drops, ointment);
- Uniflox (drops).
The list of drugs that can become an alternative to the original medication is quite extensive. However, you should not choose the analogues of "Combiflox" on your own. Before changing the medication, you should consult with your doctor to avoid extremely negative reactions.
What else can replace the original medicine?
Do you need to find an analogue as close as possible to the drug? "Combiflox" tablets can be replaced with drugs: "Ofloxacin" (200 mg) and "Ornidazole" (500 mg). It is these medicines that are the active ingredients of the original remedy.
These drugs must be taken together. Sometimes they are advised to separate them in time. In order to correctly draw up a therapy regimen (if these analogues of "Combiflox" are chosen), it is necessary to consult with your doctor.
Patient feedback
How do people react to treatment with Combiflox? Patient reviews indicate that some unpleasant reactions do appear during therapy. Most often, patients suffer from nausea, dizziness. Often, patients indicate the appearance of mental disorders, deterioration of mood.
Doctors explain the occurrence of such reactions with a high concentration of the two strongest antibiotics. At the same time, doctorsthey rush to prescribe such a strong medication to the patient. As practice shows, Combiflox drugs are resorted to only in those situations where the undertaken long-term treatment has not provided positive results.
Can analogues become an effective alternative to the original medicine? Unfortunately, in most cases, no. For example, the drug "Ofloxacin" affects only part of the pathogenic microflora. Therefore, in some diseases, the medicine may be ineffective. This feature is also characteristic of the medicine "Ornidazole".
Conclusion
Only in the right combination of the active substances ofloxacin and ornidazole can effectively rid the body of developing serious pathologies. That is why, despite the many negative symptoms that manifest themselves during therapy with Combiflox, patients indicate that the original medication really helps.
