"Polyoxidonium" (12 mg) is a drug belonging to the pharmacotherapeutic group of immunomodulating agents. Such medicines are used in cases where it is necessary to help the body in the fight against pathogens. Treatment with the drug is carried out according to certain schemes. Consider them, as well as indications, contraindications and some other nuances associated with "Polyoxidonium" (12 mg).
Active ingredient and dosage forms
In this preparation, the main substance is considered to be azoximer bromide. The component has an immunomodulatory, detoxifying, antioxidant and moderate anti-inflammatory effect.
"Polyoxidonium" at a dosage of 12 mg is available in two dosage forms. There are tablets for oral and sublingual use and suppositories (candles) that can be used both rectally and vaginally. Other dosage forms produced in12 mg dosage, no.
Additional information. Are there other dosages? In pharmacies you can see 6 mg suppositories. This dosage form is specially designed for children. A lyophilisate is also produced, from which a solution is prepared for injection and topical application. Its dosage is also not 12 mg. "Polyoxidonium" in the form of a lyophilisate contains either 3 mg or 6 mg of the active ingredient.
List of optional parts
"Polyoxidonium" contains not only azoximer bromide, but also a number of excipients. The tablets contain lactose monohydrate, potato starch, mannitol, povidone, stearic acid. The list of excipients that make up the suppositories includes cocoa butter, mannitol, and povidone.
Pharmacodynamics of the drug
The main substance "Polyoxidonium" has a complex effect on the human body:
- Immunomodulatory action is to restore the functions of the immune system. This is necessary for various diseases (for example, in secondary immunodeficiency conditions provoked by infections, the occurrence of cancer cells, injuries, postoperative complications, etc.).
- The detoxifying effect of the drug is manifested in the removal of toxins, s alts of heavy metals. When taking Polyoxidonium, the human body is cleansed of those substances that it does not need and cause harm.
- The antioxidant effect of the main substance of the drug isinhibition of lipid peroxidation (LPO). What is it for? Lipid peroxidation can lead to negative consequences. An increase in LPO products causes damage to proteins and lipids of biomembranes, changes in the structure of macromolecules, disruption of the integrity of cells and intracellular organelles.
- The anti-inflammatory effect of azoximer bromide is to reduce the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.
Polyoxidonium (12 mg) is well tolerated. Azoximer bromide has no carcinogenic, mutagenic and embryotoxic effects. Allergic reactions are possible when using suppositories. At the same time, practice shows that undesirable effects are rare. Only a small proportion of people experience vaginal itching, perianal itching, swelling and redness of the skin. There are no reported side effects of the pills.
Pharmacokinetics
Azoximer bromide quickly penetrates the mucous membranes and is distributed throughout the body. The maximum concentration of the active ingredient after taking the tablet is reached after 3 hours, and after using the suppository - after 1 hour.
Azoximer bromide in the body breaks down to low molecular weight oligomers. They are excreted mainly by the kidneys. A small proportion of oligomers (about 3%) enters the feces. The drug has no cumulative effect.
Indications for use "Polyoxidonium", 12 mg
Pills. The tablet form of the drug is prescribed for adults and children over the age of 3 years. "Polyoxidonium" helps to cope with acute and chronic (in the period of exacerbation) infectious and inflammatory diseases of the oropharynx, upper and lower respiratory tract, paranasal sinuses, inner and middle ear. Also, the drug is effective in the treatment of allergic diseases complicated by recurrent infection (bacteria, fungi or viruses). For all of the above indications, "Polyoxidonium" is used as part of complex therapy.
The drug is allowed to be used for prophylactic purposes. Monotherapy with Polyoxidonium 12mg tablets warns:
- exacerbation of chronic diseases of the oropharynx, upper and lower respiratory tract, paranasal sinuses, inner and middle ear;
- development of a herpes infection in the lips or nose;
- development of secondary immunodeficiency states due to the influence of negative factors on the body, due to aging.
Suppositories. "Polyoxidonium", produced in the form of suppositories of 12 mg, is suitable for the treatment and prevention of various infectious and inflammatory diseases in adults. In cases where the use of the drug for medicinal purposes is required, suppositories are prescribed in combination with other medicines. The list of indications is quite extensive:
- acute or exacerbated infectious and inflammatory diseases of different localization and etiology;
- various forms of tuberculosis;
- inflammatory diseases of the urogenital tract (prostatitis, pyelonephritis, cystitis,bacterial vaginosis, endomyometritis, etc.);
- allergic diseases complicated by infection (bacterial, fungal or viral);
- oncological diseases ("Polyoxidonium" in cancer reduces the negative effects of chemotherapy and radiation therapy);
- rheumatoid arthritis occurring on the background of prolonged use of immunosuppressants and complicated by any infection;
- burns and ulcers on the body, fractures (the active substance of the drug activates the recovery processes in the body).
Prophylaxis with suppositories "Polyoxidonium" 12 mg can be carried out in order to prevent the occurrence of acute respiratory infections in adults, herpes infection of the urogenital tract, secondary immunodeficiency states. Also, the drug helps to prevent the exacerbation of chronic infections. For prevention purposes, it is enough to use only Polyoxidonium suppositories without additional medicines.
List of contraindications
At first glance, it may seem that "Polyoxidonium" is useful and safe. It strengthens the immune system and does not worsen the state of he alth by side effects. However, "Polyoxidonium" is still a medicine. In some cases, it cannot be used.
Pills and suppositories have several common contraindications:
- hypersensitivity to the components contained in the composition;
- pregnancy and breastfeeding period;
- acute renal failure.
Additionally, tablets are prohibited from treating and preventing rare hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome. Also, this dosage form is not used in children under 3 years of age. Suppositories also have one additional contraindication. "Polyoxidonium" with 12 mg of the active substance in this dosage form is not intended for use in childhood. For children, as mentioned above, special suppositories are produced with 6 mg of azoximer bromide.
Caution in the use of "Polyoxidonium" is required to be observed in chronic renal failure. In this pathological condition, you must first consult a doctor. Experts generally recommend that patients with chronic renal failure do not use tablets and suppositories more than 2 times a week.
Schemes for the use of tablets for medicinal purposes
For the tablet form, several schemes of application are provided. They can be found in the table.
| How to use | Age Group | Duration of treatment and dosage |
| Oral | Adults | For the treatment of diseases affecting the upper and lower respiratory tract, "Polyoxidonium" is prescribed for 10 days. Daily dose - 2 tablets (drink not in a row, but after a sufficient period of time). |
| Children aged 10 and over | ||
| Sublingual | Adults |
Sublingual administration has several indications, each of which has its own duration of use of the medicine:
For all the indicated indications, the doses recommended are the same - 1 tablet twice a day. |
| Children over 10 | Children "Polyoxidonium" (12 mg) is administered sublingually according to the same indications as adults. For any disease, the course of treatment should last 1 week. Dosage: 1 tablet twice a day. | |
| Children aged 3 to 10 | For influenza, SARS, inflammatory processes in the oropharynx, allergic diseases with infectious complications "Polyoxidonium" is used for 1 week. Dosage - half a tablet twice a day. |
Schemes for the use of suppositories for medicinal purposes
Candles "Polyoxidonium" with 12 mg of active ingredient for any disease are used in the same doses. Vaginal administration of suppositories is indicated in the presence of any gynecological problems. Daily dose - 1 suppository. It is inserted into the vagina before going to bed. Rectal suppositories tooapply 1 time per day after bowel cleansing.
Treatment with candles may not be done every day. Features of therapy depend on the disease. With gynecological ailments, exacerbated infectious and inflammatory diseases that occur in a chronic form, treatment is carried out in two stages. The first stage is the first three days. During this period, suppositories are required to be administered daily. At the second stage, candles are applied every other day. In total, 10 suppositories should be spent during the treatment period.
Daily use of Polyoxidonium 12 mg suppositories required:
- In the presence of injuries, ulcers, burns, fractures (to activate recovery processes in the body), acute infectious processes. The course of treatment in such cases is 10 days.
- With exacerbated urological diseases. The duration of the use of suppositories is 10 days.
- In allergic diseases occurring with infectious exacerbations. Duration of treatment - 10 days.
Special treatment regimens are provided for patients with the following diagnoses:
- Pulmonary tuberculosis. During the first three days, suppositories are applied daily, and in the future, treatment is carried out every other day. The course includes 20 suppositories of 12 mg. After treatment, maintenance therapy can be carried out for 2-3 months. Its essence is the use of 6 mg suppositories twice a week.
- Oncological diseases. "Polyoxidonium" (12 mg) begins to be used before chemotherapy and radiation therapy for 2-3 days. Suppositories are administered daily, 1 pc. After that, you need to applycandles are not daily. The scheme is twice a week, and the course is up to 20 suppositories.
- Rheumatoid arthritis. With this diagnosis, suppositories are applied every other day. The course of treatment involves the use of 10 candles.
Prophylactic use of the drug
Polyoxidonium tablet form (12 mg) is used sublingually for the prevention of various diseases. Adults usually need 1 tablet per day. Duration of application - 10 days. More frequent use of the drug (1 tablet twice a day) is necessary to prevent recurrent herpes that manifests itself in the lips and nose.
Pills can also be given to children for prevention purposes. Application features can be seen in the table.
| Preventive purpose | Application diagram | |
| 3-10 years old | aged 10 and over | |
| Prevention of the development of influenza, SARS in the pre-epidemic period | Give your child half a pill every day for a week | Take 1 tablet daily for a week |
| Prevention of the occurrence of manifestations of herpes in the lips and nose |
Dosage - half a tablet twice a day Preventive course – week |
Take 2 tablets daily for a week |
| Prevention of exacerbationschronic diseases of ENT organs, respiratory tract | Give your child half a pill daily for 10 days | Take 1 tablet daily for 10 days |
Certain schemes have been established for the use of suppositories for prophylactic purposes:
- Suppositories with 12 mg of the active ingredient can help adults prevent the development of influenza and SARS. To do this, you need to inject the medicine daily (1 pc.) For 10 days.
- In order to prevent exacerbations of various chronic diseases, urogenital herpes suppositories are used every other day. In total, the medicine must be injected 10 times.
- Prevention of secondary immunodeficiencies provoked by aging is effective when the drug is used 2 times a week. The course includes 10 suppositories. You can carry out such prevention 2 or 3 times a year.
Terms of purchase and storage
The medicine is OTC, i.e. it is freely sold in pharmacies. After buying it, it is important to pay attention to compliance with storage conditions. "Polyoxidonium" (12 mg) should be in a place where moisture does not get. Recommended storage temperature:
- for tablets - 2-25 degrees;
- for suppositories - 2-15 degrees.
Polyoxidonium expiration date is 2 years from the date of manufacture.
Reviews of immunologists about "Polyoxidonium"
Many doctors give a positive assessment of "Polyoxidonium". ByAccording to experts, this drug is a pretty good immunomodulator. When used in complex therapy, it helps the body to cope with emerging diseases faster. Another positive side of the drug is the ability to use "Polyoxidonium" for the prevention of ailments. The disadvantages of many doctors include only the price of the drug. On average, a package with tablets (10 pcs.) costs 750 rubles, and a package with suppositories (10 pcs.) costs 1,050 rubles.
There are also negative reviews of immunologists about "Polyoxidonium". Experts who are negatively related to the drug say that its clinical effectiveness is not proven. A few more negative opinions: this medicine was created only for making money by the manufacturer; the drug is produced in Russia, in other countries no one knows about the existence of such a “miracle remedy”, which allows you to effectively deal with a wide range of ailments, from the flu to bacterial vaginosis.
What can replace "Polyoxidonium"
If "Polyoxidonium" for some reason is not suitable (for example, caused an allergy), then a replacement can be found for it. The group of immunomodulating agents combines many drugs. However, choosing something on your own is not recommended. Each immunomodulator has its own list of indications.
For an example, we can cite "Likopid" (active ingredient - glucosaminylmuramyl dipeptide). This drug is available in tablets. It is used in complex therapy in the treatment of adults and children from 3 years of age with chronic respiratory tract infections,herpetic infection, acute and chronic purulent-inflammatory diseases of soft tissues and skin. Prophylaxis with "Likopidom" can only be carried out by adults in order to prevent the development of diseases of the respiratory tract, ENT organs.
Can also be attributed to the analogues of "Polyoxidonium" (12 mg) candles "Genferon". This drug is a combined remedy, because it contains 3 active substances - interferon alpha, taurine, benzocaine. The first component has an antimicrobial, antiviral and immunomodulatory effect. Taurine accelerates the processes of tissue regeneration, helps to relieve inflammation, and benzocaine is a local anesthetic. This analogue of Polyoxidonium suppositories (12 mg) is used in the treatment of infectious and inflammatory diseases of the urogenital tract.
In conclusion, it is worth noting that "Polyoxidonium" has been on the pharmaceutical market for more than a year. If you study the reviews, you can understand that so many people have experienced the effect of this drug on themselves and were satisfied with its effectiveness. All the treatment was different - tablets, suppositories in accordance with the instructions for use, injections. "Polyoxidonium" with 12 mg, with 6 mg, and also with 3 mg of the active ingredient helped people to quickly cope with existing ailments, strengthen immunity to prevent the occurrence of various diseases in the future.
