Currently, there are many different remedies for hypertension and angina attacks. One of them is such as "Farmadipin" (drops) medicine. From what this drug, we will consider further in more detail.
Composition
The active ingredient in this case is nifedipine (nifedipine). In 1 ml of this solution, it is in a certain amount. Namely, when recalculated for 100% dry type substance - 20 mg. This makes thirty drops.
"Farmadipin" (drops), the instructions for use of which will be discussed below, contains such excipients as polyethylene glycol 400 and ethanol 96%.
Pharmacological properties
This drug has a peculiar pharmacodynamics. As mentioned above, "Farmadipine" (drops) contains the substance nifedipine, which has a hypotensive and antianginal effect. It helps to block the entry of calcium ions into cardiomyocytes and into certain smooth muscle cells of peripheral and coronary arteries through voltage-dependent slow correspondingchannels in cell membranes. This is an important property. Nifedipine also relaxes vascular smooth muscles, dilates peripheral and coronary arteries, and eliminates spasms. At the same time, blood pressure, peripheral vascular resistance, afterload on the heart and oxygen demand of the myocardium decrease. Also, when taking this drug, certain manifestations are still observed. Namely, there is a slight decrease in myocardial contractility and heart function, as well as a slight decrease in platelet aggregation.
Pharmacokinetics
In this regard, "Farmadipin" (drops), the instructions for use of which are discussed in this review, has its own characteristics. When taken internally, it is well absorbed in the digestive tract. Its bioavailability is about 40-60 percent. A particularly rapid development of the effect (after 5–10 minutes) is observed when sublingual administration is carried out. This is important to know. Usually the greatest effect appears after 30-40 minutes. The implementation of the meal does not particularly affect the rate of absorption of this agent. The manifestation of the hemodynamic effect will persist for 4-6 hours. At the same time, up to 90 percent of nifedipine binds to blood plasma proteins. A drug such as "Farmadipin" (drops) is metabolized in the liver. The presence of a total clearance of nifedipine ranges from 0.4 to 0.6 l / kg / h. It is excreted from the body mainly in the form of inactive metabolites. The elimination half-life can be from 2 to 4 hours. In the elderly and patients withcirrhosis of the liver, the process of metabolism of nifedipine significantly slows down. As a result, they have an indicator of the half-life of this agent can increase by about 2 times. In this case, it is required to reduce the dose and increase the intervals between taking the indicated drug. Nifedipine does not accumulate in the body. It can also penetrate the placental and blood-brain barrier in small quantities. However, it is excreted in breast milk.
Indications for use
Appointed "Farmadipin" (drops) in the following cases:
- When essential and symptomatic hypertension occurs.
- For the treatment and prevention of angina attacks.
- With hypertrophic cardiomyopathy.
- For Raynaud's disease.
Application
Take "Farmadipin" (drops) sublingually. With a sharp increase in blood pressure (for example, 180/100–190/110 mm Hg), a single initial dose of this drug for adults in general is about 3–5 drops (2–3.35 mg). Elderly patients are also prescribed a certain dosage. Namely - no more than 3 drops (about 2 mg). Also, the indicated amount can be dropped onto a small piece of cracker or sugar. The patient should keep it in the mouth as long as possible. With an insufficient result, the dosage of this drug is increased gradually until clinical effectiveness. In this case, it all depends on the individual approach. With subsequent manifestations of increased blood pressureyou should focus on the prescribed dose. There is also another specific criterion. It lies in the fact that if blood pressure has increased to 190/100–220/110 mm Hg. Art., then taking drops of this drug can be gradually increased to 10-15 (6, 7-10 mg). In this case, changes in pressure in a particular patient should be taken into account. This is important to know.
You also need to consider the presence of hypersensitivity of some patients to a drug such as "Farmadipin" (drops), reviews of which are positive. In such cases, the dosage is selected individually. Start with 3 drops and then gradually increase by 2-3 drops (1.34-2 mg) until the desired clinical effect is achieved.
It should be remembered that if the initial dose of this drug is exceeded, a sharp decrease in blood pressure may occur!
Side effect
When using a drug such as "Farmadipin" (drops from pressure), there may be manifestations of nausea, tachycardia, arterial hypotension, "tides" to the face of blood. In some cases, allergic reactions may occur in the form of swelling of the legs, skin rash. Symptoms of weakness, dizziness, headache may also appear.
Contraindications
Taking a drug such as "Farmadipin" (drops) is prohibited in the presence of hypersensitivity to its components, cardiogenic shock, severe aortic andmitral stenosis, hypotension, tachycardia, as well as during lactation and pregnancy.
Overdose
In this case, some negative symptoms may appear. Namely, an overdose of a drug such as "Farmadipin" (drops), may be accompanied by the occurrence of heart failure, shock, metabolic acidosis and seizures, a sharp drop in blood pressure. When these symptoms appear, it is necessary to resort to certain urgent measures of assistance. They consist of gastric lavage, activated charcoal, administration of calcium chloride and sympathomimetics, symptomatic therapy.
Features of use
"Farmadipin" (pressure drops) or its substitute should be used only with careful clinical monitoring of elderly patients and patients who have:
- Unstable angina.
- Severe heart failure.
- Hypertrophic cardiomyopathy.
- Acute aortic stenosis.
- Severe pulmonary hypertension.
- Acute cerebrovascular accident.
- Diabetes mellitus.
- Violations of the functionality of the kidneys and liver.
The dosage of other drugs that are used with nifedipine should be set on an individual basis. Cardiac glycosides can also be used while taking a medication such as "Farmadipin" (drops), the analogues of which are indicated below in this text.
When taking nifedipine with simultaneous intravenous administration of magnesium sulfate, pregnant women need to carefully monitor blood pressure. This should be done because there is a possibility of lowering blood pressure, which can harm both the mother and the fetus.
Patients with impaired liver function should also be carefully monitored. In severe cases, the dose should be reduced.
Nifedipine is metabolized through the cytochrome P450 3A4 system. As a result, drugs that inhibit or induce this area of enzymes may change the effect of "initial passage" or the clearance of this substance. With the concomitant use of nifedipine with drugs of this type, blood pressure should be monitored. If necessary, you should resort to reducing the dosage of a drug such as "Farmadipin" (drops).
Separate in vitro experiments revealed a relationship between the use of calcium antagonists, in this case nifedipine, and biochemical reverse changes in spermatozoa that affect the deterioration of the latter's ability to carry out fertilization.
Taking "Farmadipin" (drops), you should refrain from activities of a potentially dangerous type that require increased attention. Namely, at the same time, you should not drive vehicles, work with other mechanisms, and so on.
Interactions
"Farmadipine" (drops) has a hypotensive effect. This property contributes to the strengthening of drugs from the categoryblockers. That is, "Farmadipin" (drops) increases the effect of β-adrenergic receptors, diuretics, nitrates, other antihypertensive drugs, drugs and drinks containing alcohol, tricyclic antidepressants. In some cases, nifedipine helps to reduce the concentration of quinidine in the blood plasma. But the abolition of it significantly increases it. Thus, when using combination therapy, it is recommended to monitor the level of quinidine concentration in the blood plasma.
"Diltiazem" reduces the clearance of a drug such as "Farmadipine" (drops). "Fentanyl" significantly enhances the manifestations of the hypotensive effect. As a result, before the introduction of this drug (for less than 36 hours), you should stop taking "Farmadipine". The combined use of β-blockers with nifedipine can lead to the development of hypotension. "Farmadipine" (drops) helps to increase the concentration of theophylline, carbamazepine and digoxin in the blood. "Rifampicin" leads to a weakening of the therapeutic effect of nifedipine, while accelerating its metabolism. "Cimetidine" helps to increase the concentration of "Farmadipine" in the blood plasma.
Terms and conditions of storage
In this case, there are certain criteria. Store "Farmadipin" (drops) at room temperature in a dry place. The medicine must be protected from light and out of the reach of children. The storage of this drug is designed for up to 1 year and6 months. After the bottle is opened - 28 days.
Vacation
"Farmadipin" (drops) is sold exclusively by prescription.
Packaging
In vials of 25 ml or 5 ml. They are included in the pack.
"Farmadipin" (drops): analogues in Russia
There are many substitutes for this drug. The main ones are:
- "Kordipin".
- "Nifedipine".
- "Adalat".
- "Cordaflex".
- "Corinfar Uno".
- "Kordaflex RD".
- "Phenigidine".
- "Osmo-adalat".
- "Kordipin retard".
- "Kordipin xl".
Conclusion
Now you know what a medicine like "Farmadipin" (drops) is, what it helps with and what properties it has. In any case, before taking this drug, you should seek the advice of a qualified doctor.
